Staff Genes in Behaviour and Health (Research)

Wonu Akingbuwa

Wonu Akingbuwa is a post-doctoral researcher in the field of statistical genetics, investigating the role of genetic variants in psychiatric traits across the allele frequency spectrum. The interdisciplinary nature of het academic training and research experience means that she has gained an appreciation for the importance of using different approaches to investigate psychiatric aetiologia. As such her main research interests lie in the integration of different analytical techniques in order to gain a well-rounded view of the processes underlying psychopathology. She has used methods such as structural equation modelling, polygenic score analyses, and rare variant analyses using exome sequenced data, to investigate different psychiatric phenotypes including schizophrenia and depression. She teaches the course Gene Finding: Genome-Wide Association Studies and beyond, alongside Jouke-Jan Hottenga.

Meike Bartels

Meike Bartels is Professor in Genetics and Wellbeing at the department of Biological Psychology and the Director of the research Master Genes in Behaviour and Health. Instead of wondering why people are ill and invest largely in unraveling the risk factors, she wonders why so many people are protected or resilient. Why do many individuals stay healthy and happy even when faced with severe adversity? What are the protective factors? And finally, why are most people happy most of the time? Within her line of research, she wants to contribute to finding answer to these societally highly relevant questions by applying an interdisciplinary focus on genetics, environment, and its complex interplay. Her strong interest in individual differences is also reflected in the course Personalised Medicine and Health, that she coordinates in the research Master. In this course the past, present, and future of personalized medicine is discussed in detail to give the students more insight into the challenging, complex, but bright future of medicine with all the knowledge that is created based on behavioural and molecular genetic studies. The Master Genes in Behaviour and Health is headed by Meike Bartels. She also supervises the internship in the 2nd Masters year.

Elsje van Bergen

Elsje van Bergen studies causes and consequences of individual differences in learning. She integrates theories and methods from psychology, education, and genetics to study educational achievement and difficulties. For example, she studies the interplay between genetic and environmental influences on educational skills like reading. Elsje van Bergen is an Associate Professor at Biological Psychology and LEARN!, the Vrije Universiteit Amsterdam. Before taking up this position she was a postdoctoral research fellow in developmental psychology at the University of Oxford. She obtained he PhD in educational sciences at the University of Amsterdam. She was a Rubicon Fellow, Oxford Junior Research Fellow (both 2012-2015), and Veni Fellow (2016-2020) and the recipient of early career awards from the Society for the Scientific Study of Reading, the Association for Psychological Science, and the Federation of Associations in Behavioral & Brain Sciences. Courses: Grant Writing and Science Communication Website: www.evanbergen.com Twitter: @drElsje and @NTRscience

Anouk den Braber

Anouk den Braber has a background in Biomedical Sciences (BSc) and Neurosciences (MSc) and obtained extensive experience with twin modelling and neuroimaging genetics analysis during her PhD and Postdoc position at the department of Biological Psychology (2008-2014). Since 2014, Anouk is co-PI of the longitudinal PreclinAD Twin60++ study that aims to validate existing and discover new markers for early Alzheimer’s Disease pathology in cognitively normal elderly individuals; identify prognostic markers for cognitive decline in cognitively normal subjects with Alzheimer’s Disease pathology and determine the contribution of genetic and environmental influences on these markers. Using samples from the NTR biobank study they are currently investigating the added value of plasma biomarkers for AD diagnosis and prognosis. Courses: Anouk is a teacher in the courses Introduction to omics and Brain Imaging Genetics.

Conor Dolan

Conor Dolan is a professor at the department of Biological Psychology (VU). His main interest is in genetic statistical modeling in the context of genetically informative designs (notably the classical twin design) with the aim of addressing interplay among genotypic and environmental variables. His recent work has addressed the use of polygenic scores in the study of interplay in genetically informative designs. Courses: Statistical programming in R and Python, Behavioural Genetics, Complex Trait Genetics.

Jenny van Dongen

Jenny van Dongen is an Assistant Professor at the Department of Biological Psychology at the VU Amsterdam. She holds a bachelor’s degree in biology (cum laude), a master’s degree in neurosciences (cum laude), and obtained her PhD (cum laude) in 2015 at the Vrije Universiteit Amsterdam on her thesis entitled “(Epi) genetics and twins”. She is interested in how the interplay between the genome, epigenome (DNA methylation), and environment gives rise to variation in complex traits. She received grants from the Amsterdam Public Health Institute and the Amsterdam Reproduction and Development Institute to study epigenetic signatures of asthma and monozygotic twinning. She is the secretary of the research master Genes in Behaviour and Health. Courses: Epigenomics and Sequencing in Behaviour and Health, Complex Trait Genetics.

Dennis van 't Ent

Dennis van 't Ents research interest lies in investigating individual differences in brain structure and function and how these differences relate to individual variation in behavioural characteristics. To this end, he collects and analyses neuroimaging data (obtained primarily through Magnetic Resonance Imaging (MRI)) in genetically informative samples from monozygotic and dizygotic twins and additional relatives. In terms of the merits of this work, he particularly likes to highlight the results of collaborations with international consortia (such as the ENIGMA consortium). Combining genome, brain and behaviour data from research institutes around the world results in large datasets with increased statistical power to find relevant differences. Large-sample studies powered by these collaborative efforts have provided important insights into the genetics of brain structure and function and the biological pathways of behavioural differences and neurological and psychiatric diseases. Van 't Ent is a coordinator and teacher of various courses in the VU's bachelors degree program in psychology. For the research master Genes in Behaviour and Health he is involved in the coordination and teaching of the 1st year course Brain Imaging genetics.

Eco de Geus

The leitmotiv of de Geus’ research is the psychophysiological study of individual differences in behavior and health. Controlled experiments and genetic epidemiological strategies are used to test contribution of genes, stress and regular exercise to cardiovascular health and mental health. Mental health is studied by a variety of survey measures and diagnostic interviews (e.g. CIDI). Cardiovascular health is studied in the laboratory by recording cardiovascular, hormonal and metabolic responses to standardized conditions, and in “real life” by using ambulatory measurements of blood pressure, cortisol, and the autonomic nervous system with the VU University Ambulatory Monitoring System (VU-AMS, www.vu-ams.nl). This is a system de Geus developed for 24-hour recordings of peripheral physiology. It is currently used world-wide by over 50 research groups to study stress and emotion in naturalistic settings. In the study of psychological and cardiovascular health a genetic perspective is introduced by means of longitudinal twin family designs and molecular genetic approaches, including candidate gene studies and whole-genome association using SNPs. The genetic architecture of autonomic nervous system activity and regular exerciser behaviour are current focus areas of research. In these areas de Geus emphasizes the gene-environment correlation and interaction perspectives, e.g. by looking explicitly also at gene-stress and gene-exercise interactions, and the use of genetically informative studies to unravel causality.

René Pool

René Pool has a background in medicinal chemistry (VU). He has received his PhD at the University of Amsterdam in the field of Computational Physics & Chemistry. Since 2012 he works as assistant professor at the department of Biological Psychology. Here he works on the metabolomics data sets collected by the Netherlands Twin Register (NTR). These data comprise hundreds of metabolic variables measured in over 6000 NTR subjects. Biologically, the metabolome can be viewed as an intermediate level in the framework starting at the genome and ending at biological function, e.g. behaviour. Metabolomics can therefore be utilized to gain detailed insights in biological (dis)function. The field of metabolomics brings together his interests in (bio)chemistry, in systems biology and in analyses of multi-dimensional data. Apart from metabolomics he actively manages the VU Biological Psychology polygenic risk score data resource comprising of risk scores in NTR for almost 250 phenotypes. As a result of his interest and experience in computational science, he is the faculty contact for High Performance Computing. Courses: Introduction to omics (RM Genes in Behaviour and Health), Molecular Genetics (Bachelor Psychology, third year)

Bruno Sauce

Biography: I started as a biology major in Brazil and obtained a master's in molecular genetics and evolution at UFSCar. I then moved to the US and towards psychology (a late-blooming passion) – I got a master’s in psychology and did a PhD in neuroscience at Rutgers University. After that, I moved to Sweden to work as a postdoc at Karolinska Institute. In 2021, I moved to the Netherlands and I now am an assistant professor at the VU in the department of biological psychology. Throughout all this moving around, I’ve done research on a bunch of topics: the evolution of sociality, the genetic architecture of maternal care, the transmission of stress and metabolic disorders across generations, the psychometrics of attention, working memory, and intelligence, the anatomical and molecular factors behind brain plasticity, the efficacy of cognitive enhancement, etc. Right now, my research focuses on the gene-environment interplay of cognitive abilities. I want to know the impact of certain experiences (like playing video games, growing up in wealth/poverty, and physically exercising) on the way we think and learn, and how much this depends on our different genetic backgrounds. I am coordinator of internship I, and coordinator of the course Nature of nurture: gene-environment correlation and interaction in the family. My personal page can be found at brunosauce.net